Please use this identifier to cite or link to this item: https://rep.polessu.by/handle/123456789/16938
Title: Role of neuronal cell adhesion molecules and N-cadherin in passive avoidance training of rats
Authors: Zhernosekov, D.D.
Nerush, P.A.
Keywords: NCAM
N-cadherin
neocortex
hippocampus
processes of memory formation
amnesia
Issue Date: 2000
Citation: Zhernosekov, D.D. Role of neuronal cell adhesion molecules and N-cadherin in passive avoidance training of rats / D.D. Zhernosekov, P. A. Nerush // Neurophysiology. – 2000. – Vol. 32, Issue 6. – Р. 368-370.
Abstract: A comparative study of the role of specific adhesion proteins, NCAM (neuronal cell adhesion molecules) and N-cadherin, was carried out on rats subjected to passive avoidance training procedure. It was shown that antibodies against the Ca2+-dependent adhesion protein N-cadherin injected into the rat somatosensory cortical zone 6 h after passive avoidance training had been completed did not evoke a loss of the habit by experimental animals. At the same time, an absolute amnestic effect with respect to this reflex developed after injection of antibodies against NCAM. After injection of antibodies against the above-mentioned proteins into the dorsal part of the hippocampus, the avoidance habit also disappeared in the case of treat-ment with antibodies against NCAM and was kept under the influence of antibodies against N-cadherin. The data obtained testify that NCAM and N-cadherin play dissimilar roles in the formation of a memory trace in the course of training.
Appears in Collections:Публикации сотрудников / Publications of the teaching stuff of Polessky State University



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