Glycine receptors in the nervous tissue and their functional role

Abstract

The literature data on glycine metabolism in neural tissue, the mitochondrial Glycleaving system, and the Gly uptake system in neural and glial cells are summarized. Brief description of localization and abundance of glycine receptors and specific binding sites in the mammalian nervous tissue is given. Four types of glycine binding receptors are described. These include own specific glycine receptor (GlyR), ionotropic glutamate receptor, which selectively binds NmethylDaspartate selectively (NMDAR), and ionotropic receptors of γaminobutyrate (GABAAR, GABACR).