Изменения активности АТР- и Са2+-зависимого протеолиза в клетках феохромоцитомы РС12, вызванные воздействием плазминогена и фактора роста нервов

Abstract

The activity of ATP- and Ca2+-dependent proteases was studied in pheochromocytoma PC 12 cells after their cultivation with plasminogen (Pg) and nerve growth factor (NGF) in different concentrations or with combination of Pg + NGF. It was found that a short-term exposure of pheochromocytoma PC 12 cells to Pg and NGF induced noticeable changes of proteolysis. These changes have complex character, in the dependence on Pg and NGF concentrations and combinations. In fact, presented data firstly illustrate the metabolic effect of Pg at cells. It mechanism is unclear until, and this phenomen nature is complex task for study in perspective.