Состояние гемостаза при введении рекомбинантного тромболитика “Триаза”

Abstract

Subject of inquiry: a blood practically able-bodied 16 donors - volunteers. The purpose of work: to estimate agency of a specimen “Triasa" on system of a hemostasis and rheologic properties of a blood. As a result of the lead work for the first time it fixed, that the thrombolytic“ Triasa" oppresses functional (the adhesion and an aggregation) properties of platelet, results in down stroke of concentration of fibrinogen, accompanying with decrease of quantity of solvable complexes of monomers of a fibrin. At application of a specimen “Triasa” shortening a time of a fibrinolysis that testifies to intensifying of fibrinolytic potential is revealed. Taking into account that the time of the fibrinolysis practically did not change, it is possible to speak about absence of contact activation during an incubation of a blood with a thrombolytic “Triasa”. Application of a specimen in the most active (in the attitude of agency on a fibrinolysis) concentrations -300 Unit/mg is accompanied by augmentation of the activated particulate thromboplastin time and a thrombin time, decrease of magnitude of a prothrombin ratio and concentration of solvable complexes of monomers of a fibrin. Samples of a blood under agency of a specimen “Triasa” are characterized by down stroke of viscosity in all researched velocity band of alteration; down stroke of an index of a defonvability of erythrocytes is marked.