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Title:	Участие активных форм кислорода в протеолитических реакциях
Other Titles:	Participation of active oxygen forms in proteolytic reactions
Authors:	Пыжова, Н.С. Никандров, В.Н. Pyzhova, N.S. Nikandrov, V.N.
Keywords:	кислород протеолиз энзиматический гидролиз
Issue Date:	1998
Publisher:	Минск : БелЦНМИ
Citation:	Пыжова, Н.С. Участие активных форм кислорода в протеолитических реакциях / Н.С. Пыжова, В.Н. Никандров // Достижения медицинской науки Беларуси: рецензируемый научно-практический ежегодник / Бел. Центр науч. мед. информации, Академия мед. наук РБ. – Минск : БелЦНМИ, 1998. – Вып. 3. – С. 94.
Description:	The possibility of participation of active oxygen forms in the catalytic function of metalloproteinases and amylases and in chymotrypsin activation was demonstrated, as well as superoxide-converging ability of pepsin and trypsin, which is inhibited by chelating agents. The ability of subcellular fractions of mouse brain and liver to activate human plasminogen (which is sensitive to active oxygen forms scavengers and inhibitors of energy metabolism) was established. The whole complex of the original data develops the authors’ hypothesis of oxygen-dependent reactions of proteolysis, which will enable to reinterpret enzymic hydrolysis mechanisms and substantiate he ways of hydrolase activity correction in biological substrates.
Appears in Collections:	Публикации сотрудников / Publications of the teaching stuff of Polessky State University

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