Estimations of cancer cells activity using modified thio-nucleosides

Abstract

Thio-nucleosides, a group of chemicals generated from nucleosides by replacing the oxygen atom with a sulfur atom, have received a lot of attention in cancer research because of their potential anticancer effects. Thio-nucleosides’ unusual chemical structure confers specific biological activity, making them possible cancer therapeutic possibilities. This article will look at the role of thio-nucleosides as anticancer medications and how they work to limit cancer cell growth and induce apoptosis. Thio-nucleosides have demonstrated exceptional cytotoxic effects on a variety of cancer cell lines, making them a promising target for future preclinical and clinical research. Their capacity to interfere with nucleic acid metabolism and impair DNA replication and repair mechanisms in cancer cells has made them viable chemotherapeutic agents. Furthermore, thio-nucleosides have demonstrated the ability to overcome drug resistance, a significant obstacle in cancer treatment, opening up new pathways for the creation of effective anticancer medicines. In this article, we will look at the molecular processes underpinning thio-nucleosides’ anticancer activities, their pharmacokinetic characteristics, and the present state of research into their therapeutic uses. Furthermore, we will investigate the obstacles and possibilities connected with using thio-nucleosides as a novel class of anticancer medications, offering insight on the future prospects and possible effect of this burgeoning field of cancer therapies.