Analysis of antibacterial activity of cytidine 3`,5`-cyclic monophosphate in Proteus mirabilis

Abstract

The incidence of antibacterial resistance is on continued rise with a threat to return to the “pre-antibiotic” era. This has led to emergence of such bacterial infections, which are essentially untreatable by the current armamentarium of available treatment options. Various efforts have been made to develop the newer antibacterial with novel modes of action, which can act against these multi-drug resistant strains. Modified nucleotides are one of the important drugs class from an antibacterial perspective. A pharmacologically diverse class of drugs that arose from chemically modified natural ribose or 2′-deoxyribose nucleosides.