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Please use this identifier to cite or link to this item: https://rep.polessu.by/handle/123456789/33378
Title: Flow-cytometric analysis of reactive oxygen species in cancer cells under treatment with brassinosteroids
Authors: Kisselev, P.A.
Panibrat, O.V.
Sysa, A.R.
Anisovich, M.V.
Zhabinskii, V.N.
Khripach, V.A.
Keywords: brassinosteroids
28-homocastasterone
cancer cell line A549
anticancer
reactive oxygen species
Issue Date: 2017
Citation: Flow-cytometric analysis of reactive oxygen species in cancer cells under treatment with brassinosteroids / P. A. Kisselev, O. V. Panibrat, A. R. Sysa [et al.] // Steroids. – 2017. – Vol. 117. – P. 11-15. – DOI: 10.1016/j.steroids.2016.06.010.
Abstract: To explore the underlying mechanism of cancer cell growth inhibition by brassinosteroids (BS), reactive oxygen species (ROS) generation under treatment with 28-homocastasterone and its synthetic derivatives (22S,23S)-28-homocastasterone was measured in A549 human lung adenocarcinoma cells. BS induced ROS generation in A549 cells and their growth in a time and dose-dependent manner. The maximal effect was observed for (22S,23S)-28-homocastasterone which at 30lM concentration showed a 6-fold increase of ROS generation in comparison with the control.
Appears in Collections:Публикации сотрудников / Publications of the teaching stuff of Polessky State University

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