Please use this identifier to cite or link to this item: https://rep.polessu.by/handle/123456789/33458
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dc.contributor.authorChen, X.-
dc.contributor.authorSysa, A.G.-
dc.contributor.authorLyu, J.-
dc.contributor.authorYang, F.-
dc.date.accessioned2025-02-04T11:37:02Z-
dc.date.available2025-02-04T11:37:02Z-
dc.date.issued2024-
dc.identifier.citationThe critical role of adenine nucleotide translocase 4 (ANT4) in male reproductive function: insights from a mouse model / X. Chen, A.G. Sysa, J. Lyu, F. Yang // Actual environmental problems : proceedings of the XIV international scientific conference of young scientists, graduates, master and PhD students, Minsk, Republic of Belarus, 05-06 December 2024 / International Sakharov Environmental Institute of Belarusian State University ; edited by: A. Rodzkin, M. Germenchuk. – Minsk, 2024. – P. 165-166.ru
dc.identifier.urihttps://rep.polessu.by/handle/123456789/33458-
dc.description.abstractAdenine nucleotide translocator 4 (ANT4) is an ATP/ADP transporter crucial for male fertility, yet its comprehensive role in reproductive function remains unclear. This study utilized ANT4 knockout mice to elucidate the effects of ANT4 deficiency on male reproduction. We observed that ANT4 deficiency led to infertility and impaired testicular development. Further investigation revealed significant alterations in testicular oxidative stress, autophagy, and inflammation. Specifically, ANT4 loss resulted in an imbalance between oxidation and antioxidants, affected autophagic flux and the AKT-AMPK-mTOR signaling pathway, and increased pro-inflammatory factor expression. These findings underscore ANT4's importance in regulating oxidative stress, autophagy, and inflammation in testicular tissues, providing a nuanced understanding of its significance in testicular development and male fertility.ru
dc.language.isoenru
dc.publisherMinsk-
dc.rightsоткрытый доступru
dc.subjectadenine nucleotide translocator 4 (ANT4)ru
dc.subjectmale reproductionru
dc.subjectoxidative stressru
dc.subjectautophagyru
dc.subjectinflammationru
dc.subjectmitochondrial functionru
dc.subjectspermatogenesis-
dc.subjectmouse model-
dc.titleThe critical role of adenine nucleotide translocase 4 (ANT4) in male reproductive function: insights from a mouse modelru
dc.typeArticleru
Appears in Collections:Публикации сотрудников / Publications of the teaching stuff of Polessky State University

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