Regulation of mitochondrial activity by inclusion complexes of aminophenols and antimetabolites with β-cyclodextrins

Abstract

As a by-product of normal metabolism (endogenous sources) and because of exposure to environmental compounds (exogenous sources), reactive oxygen species (ROS) are formed in all living organisms. Endogenous ROS are largely formed during oxidative phosphorylation in the mitochondria and, therefore, mitochondrial DNA (mtDNA) is at particularly high risk of ROS-induced damage. Mitochondria are essential for cell viability, and oxidative damage to mtDNA has been implicated as a causative factor in a wide variety of degenerative diseases, and in cancer and aging.