Please use this identifier to cite or link to this item: https://rep.polessu.by/handle/123456789/17089
Title: Возможный механизм специфического влияния кладрибина на развитие экспериментального аллергического энцефаломиелита
Other Titles: The possible mechanism of specific influence of cladribine on development experimental allergic encephalomyelitis
Authors: Жук, О.Н.
Калюнов, В.Н.
Кожанова, В.Ф.
Лукашевич, В.С.
Лукашевич, И.Б.
Полукошко, Е.Ф.
Тумилович, М.К.
Keywords: кладрибин
аллергический энцефаломиелит
Issue Date: 2002
Publisher: Минск : Триолетта
Citation: Возможный механизм специфического влияния кладрибина на развитие экспериментального аллергического энцефаломиелита / О.Н. Жук [и др.] // Сахаровские чтения 2002 года: экологические проблемы XXI века: мат. международной конф. ведущих специалистов, молодых ученых и студентов, Минск, 17-21 мая 2002 года / Мин-во образования Респ. Беларусь, Международный гос. экологический ун-т им. А. Сахарова; под общ. ред. А.А. Милютина. – Минск : Триолетта, 2002. – С. 86-88.
Abstract: The influence of cladribine on development and outcome ol EAE, and also on some morphological, biochemical and immunoiogical parameters of Guinea pigs was analyzed. The ability of cladribine to mediated trophic effects on sympathoblasts in vitro was estimated The treatment with cladribine has resulted in elongation of an incubation interval with 12±0,51 d in the control up to 18±2,28 d in experiment (P< 0,05), softening of gravity of the chronic form and augmentation of number of objects not showing attributes of a pathology, it rendered modulating action on parameters of the immune answer. In vitro cladribine (10 ng/ml) enhanced effects of NGF on cell - targets, elevating a surviving of neuroblasts and stimulating neuritogenesis. It stimulated production and secretion of the trophic agents trom neurones and non-neuronal cells of mature cultures of a neocortex, it Is possible NGF. It is supposed, that besides immunosuppresive effect, one of mechanisms of favourable influence of cladribine on EAE may be rising of enhansing of synthesis NGF by cells oi a neuroglia in vivo. However additional researches are necessaryfor the final conclusion.
Appears in Collections:Публикации сотрудников / Publications of the teaching stuff of Polessky State University



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