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4. Публикации сотрудников / Publications of the teaching stuff of Polessky State University

Title:	Противовирусные свойства терпеновых производных и их ингибиторная активность в отношении протеиназ
Other Titles:	Antiviral properties of terpene derivatives and their inhibitory effect on proteinases
Authors:	Бореко, Е.И. Павлова, Н.И. Николаева, С.Н. Савинова, О.В. Еремин, В.Ф. Никандров, В.Н. Boreko, E.I. Pavlova, N.I. Nikolayeva, S.N. Savinova, O.V. Eremin, V.F. Nikandrov, V.N.
Keywords:	вирус протеиназы
Issue Date:	2002
Publisher:	Минск : ГУ РНМБ
Citation:	Противовирусные свойства терпеновых производных и их ингибиторная активность в отношении протеиназ / Е.И. Бореко, Н.И. Павлова, С.Н. Николаева, О.В. Савинова, В.Ф. Еремин, В.Н. Никандров // Достижения медицинской науки Беларуси: рец. науч.-практ. ежегодник / Респ. науч. мед. б-ка, Бел. акад. мед. наук; редсовет И. Е. Гурманчук [и др.]. – Минск : ГУ РНМБ, 2002. – Вып. VII. – С. 50-51.
Description:	The antiviral properties of 52 lupane and some other terpenes were investigated in cell cultures infected with herpes simplex type 1 (HSV-1), influenza A/FPV/Rostock and ECHO 6 viruses. It was found that the known (betulin, betulinic and betulonic acids) and new triterpenes have antiviral activity against HSV-1. A number of new com­ pounds had higher antiviral properties in HSV-1 experiments as compared with the known triterpenes. A combination of the substitutes in positions 3 and 28 of lupine triterpene was important for the antiviral activity in this case. The 3-oxo derivatives with L-amino acids in position 28 were the most active. Antiviral properties of new lupine triterpenes against influenza virus were determined for the first time. Their activity mostly correlated with oxime or amide group in positions 3 or 28. Among other compounds active against influenza virus allobetulin is most remark able. The substitutes more than a half of compounds active against HIV-1 were N-substituted amides. Betulinic acid has antiviral activity against ECHO 6 virus, and is characterized by a relatively insignificant virus titer decrease in a wide concentration range. Inhibition of some serine, cysteine and aspartic proteinases was observed in the presence of triterpenes studied.
Appears in Collections:	Публикации сотрудников / Publications of the teaching stuff of Polessky State University

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