Модификация иммунного ответа при атеросклерозе

Abstract

Purpose: estimate a structurally functional state of a chromatin of nucleus of lymphocytes at patients with an atherosclerosis. The method of morphodensitometry gives the possibility to study cytological objects on a new quality level. Analysis of a chromatin at patients with an atherosclerosis in comparison with control group has shown, that nucleus of lymphocytes at patients with an atherosclerosis have smaller perimeter and absorbency. Differences are found in patients of the basic group in heterochromatin areas of nucleus of lymphocytes in comparison with control group: decrease of dispersity granular components, but augmentation of its contrast; decrease of the general area and perimeter of perigranular zone than at healthy people. Change of the parameters describing a state of perigranular zone, is a marker of structurally functional rearrangements of a chromatin of the lymphocytes connected to an atherosclerosis. During atherosclerosis are modifications of immune response.