Модуляция углеводно-энергетического метаболизма клеток нервной ткани при воздействии плазминогена и стрептокиназы

Abstract

Based on the study of the activity of lactate dehydrogenase, succinate dehydrogenase and glucose-6-phosphate dehydrogenase as parts of glycolysis,tricarbonic acid cycle and pentose-phosphate pathway on glioma C6 cells and dissotiated neocortex cultures, plasminogen has been shown for the first time to inhibit lactate production, oxidation in tricarbonic acid cycle and to enhance the activity of pentose-phosphate pathway (in neocortex only). In both types of cell cultures, streptokinase significantly enhances the accumulation o f lactate,strongly activates the pentose-phosphate pathway and inhibits oxidation in the tricarbonic acid cycle.