О роли цитокинов и молекул клеточной адгезии в патогенезе атеросклероза у людей, подвергшихся радиационному воздействию, которые проживают на территории, загрязненной радионуклидами

Abstract

Mechanisms of intercellular communication disturbances during atherogenesis studies were investigated in 29 patients with atherosclerotic lesions. The research of the initial cytokines (IL-la, IL-lp, IL-6, IL-8, IL-IO, endothelin-I) and soluble cell adhesion molecules (P-, E-selectins, ICAM-I, VCAM-I) levels and changes in their concentrations in response to coagulation and high shear stress using developed technique are presented. Atherosclerotic lesions of vascular walls were shown to correlate with increased levels of all intercellular adhesion molecules and inflammatory cytokines (IL-lp and IL-6). Distinct elevation of cytokines and bidirectional concentration changes of intercellular adhesion molecules was demonstrated. Soluble cell adhesion molecules were proposed to play pathophysiological role in downregulation of cytokines secretion. Thus, proposed interdisciplinary approaches are adequate for research of molecular and cell mechanisms of atherogenesis and worth further development.