Hematological and Biochemical Status in Norm and with LPS-Induced General Inflammation

Abstract

The present study investigated the effects of E. coli lipopolysaccharide (LPS) induced mastitis model in rat on the activity of antioxidant enzyme systems under modified nucleosides/nucleotides administration. To achieve this purpose, E. coli LPS was injected intraperitoneally. The antioxidant activities of the enzymes, superoxide dismutase, glutathione peroxidase, and catalase together with malondialdehyde (MDA) level were assayed in blood serum. Results obtained showed that, the antioxidant enzyme activities were significantly decreased while the level of MDA, the indicator of lipid peroxidation were significantly increased following intramammary inoculation of LPS compared to the control animals. The results indicated that E. coli LPS-induced mastitis could alter antioxidant enzymes and increase lipid peroxidation.